CYP3A4 inducers may raise the formation from the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Closely keep track of clients using ifosfamide with CYP3A4 inducers for toxicities and consider dose adjustment.
pentobarbital will lower the extent or result of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Pitolisant exposure is lowered by fifty% if coadministered with powerful CYP3A4 inducers.
Stay away from coadministration of ganaxolone with average or strong CYP3A4 inducers. If coadministration unavoidable, consider rising ganaxolone dose; on the other hand, do not exceed highest everyday dose for pounds.
Contraindicated (one)pentobarbital will reduce the extent or outcome of lorlatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the level or influence of estropipate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will lower the level or influence of bosentan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.
pentobarbital will reduce the level or outcome of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the extent or outcome of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not encouraged; potent cytochrome P450 enzyme inducers lessen systemic exposure to roflumilast and will lessen the therapeutic success
pentobarbital will decrease the extent or effect of nateglinide by influencing hepatic enzyme CYP2C9/10 metabolism. Use Warning/Monitor.
pentobarbital will minimize the level or outcome of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Solid or reasonable CYP3A4 inducers may maximize amount of diazepam elimination; for that reason, efficacy of website diazepam could possibly be diminished.
pentobarbital will lessen the level or influence of diltiazem by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will boost the level or effect of clopidogrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
To minimize the potential for overdosage or the development of dependence, limit the prescribing and dispensing of sedative-hypnotic barbiturates, to the quantity required to the interval right until the following appointment
pentobarbital will lessen the level or influence of alfentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.